منابع مشابه
Multi-Omics Data Integration: A Modular Approach
Substantial extent of research has been carried out over past few decades to understand the molecular and genetic level information within the cell that help improving the methodologies in the fields of agricultural or medical research. However, often the research is focused at one particular area of expertise by an individual researcher or a work group and very less number of attempts were mad...
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The identification of good targets is a critical step for the development of targeted therapies for cancer treatment. Here, we used a multi-omics approach to delineate potential targets on chromosome 20q, which frequently shows a complex pattern of DNA copy number amplification in many human cancers suggesting the presence of multiple driver genes. By comparing the amounts of individual mRNAs i...
متن کاملBreast Cancer Prognostics Using Multi-Omics Data
Breast cancer affects one in eight women in America and is a leading cause of death from cancer worldwide. In the current study, four types of Omics data including copy number variation, gene expression, proteome and phosphoproteome were collected from seventy-seven breast cancer patients. Individual types of Omics data were used to separately construct predictive models to predict ten-year sur...
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37 38 Running title: Using multi-omics for probiotic selection 39 40
متن کاملGlobal proteomics profiling improves drug sensitivity prediction: results from a multi-omics, pan-cancer modeling approach.
Motivation Proteomics profiling is increasingly being used for molecular stratification of cancer patients and cell-line panels. However, systematic assessment of the predictive power of large-scale proteomic technologies across various drug classes and cancer types is currently lacking. To that end, we carried out the first pan-cancer, multi-omics comparative analysis of the relative performan...
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ژورنال
عنوان ژورنال: Nature Reviews Genetics
سال: 2016
ISSN: 1471-0056,1471-0064
DOI: 10.1038/nrg.2016.95